Abstract | OBJECTIVES: METHODS: RESULTS: The study population comprised 2,008 women with median (95% range) gestational age of 10 (6-14) weeks. There was no association between PFAS and TSH. Higher PFNA, PFDA, PFHpA and PFOA levels were associated with a higher FT4 (largest effect estimate for PFDA: β [95% CI]: 0.27 [0.10 to 0.45], P = 0.002). Higher PFUnDA levels, but no other PFAS, were associated with a lower FT3 (β [95% CI]: -0.05 [-0.09 to -0.01], P = 0.005). Higher PFUnDA levels were associated with lower TT4 (β [95% CI]: -1.58 [-3.07 to -0.09]) and there was an inverted U-shaped association of PFOS with TT4 (P = 0.03). Higher PFDA, PFUnDA, PFHpA levels were associated with a lower TT3. Overall, higher PFAS concentrations were associated with a higher FT4/FT3 ratio and a higher TT4/TT3 ratio. There was no association of PFAS with the TSH/FT4 ratio. Higher concentrations of several PFAS were associated with lower TT4/FT4 and TT3/FT3 ratios. CONCLUSIONS: These findings translate results from experimental studies suggesting that exposure to PFAS may interfere with the thyroid system during pregnancy. Further experimental studies should take into account human evidence to better understand the potential underlying mechanisms of thyroid disruption by PFAS exposure.
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Authors | Arash Derakhshan, Andreas Kortenkamp, Huan Shu, Maarten A C Broeren, Christian H Lindh, Robin P Peeters, Carl-Gustaf Bornehag, Barbara Demeneix, Tim I M Korevaar |
Journal | Environment international
(Environ Int)
Vol. 167
Pg. 107420
(09 2022)
ISSN: 1873-6750 [Electronic] Netherlands |
PMID | 35870378
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2022 The Authors. Published by Elsevier Ltd.. All rights reserved. |
Chemical References |
- Fluorocarbons
- Thyroid Hormones
- Triiodothyronine
- Thyrotropin
- Thyroxine
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Topics |
- Asthma
- Child
- Environmental Illness
- Female
- Fluorocarbons
- Homeostasis
- Humans
- Hypersensitivity
- Infant
- Pregnancy
- Sweden
- Thyroid Gland
- Thyroid Hormones
- Thyrotropin
- Thyroxine
- Triiodothyronine
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