The roles and diagnostic value of miRNA-1246 in the serum of patients with intracranial aneurysms.

Abstract

Background:

Inflammatory response is one of the important factors affecting the formation of intracranial aneurysm. miR-1246 is involved in the regulation of several inflammatory diseases; however, its expression levels and the mechanism of action in intracranial aneurysms remain further investigated.

Methods:

Bioinformatics was used to analyze the levels of micro-RNAs (miRNAs) in the serum of intracranial aneurysm patients as well as in the intracranial aneurysm tissues downloaded from the GEO RNA-seq database. Blood samples were collected pre-operatively from patients with intracranial aneurysms as well as from healthy volunteers, and miRNA-1246 expression levels were detected using quantitative reverse transcriptase polymerase chain reaction. Meanwhile, the diagnostic value of miR-1246 for intracranial aneurysm was explored using the receiver operating characteristic (ROC) curve.

Principle findings and results:

Serum levels of miR-1246 were elevated in intracranial aneurysm patients. Bioinformatics studies revealed that the target genes of miR-1246, TP53, glycogen synthetase kinase (GSK), and transcription factor YY1 may play important roles in the development of intracranial aneurysms. miR-1246 is involved in inflammatory response, lipid, and atherosclerotic signaling pathways.

Conclusions and significance:

High level of miR-1246 is found in the serum of patients with intracranial aneurysms and may serve as a diagnostic or/and treatment marker for intracranial aneurysms.

• Authors: Haijie Jiang, Yansheng Ding, Lili Wu, Chunyan Jiang, Chengdong Wang
• Journal: Translational neuroscience (Transl Neurosci) Vol. 13 Issue 1 Pg. 172-180 (Jan 01 2022) ISSN: 2081-3856 [Print] Germany
• PMID: 35860808 (Publication Type: Journal Article)
• Copyright: © 2022 Haijie Jiang et al., published by De Gruyter.