Expression Profile of Immunoglobulin G Glycosylation in Children With Epilepsy in Han Nationality.

Abstract

Background:

Epilepsy is a chronic brain disease that recurs during childhood, and more than half of adult epilepsy originates from childhood. Studies suggested that immunoglobulin G (IgG) glycosylation are closely related to neurological diseases. Here we analyzed the characteristics of the immunoglobulin glycosylation profile of children with epilepsy.

Methods:

Patients were recruited in Taian, Shandong Province from December 2019 to March 2020. Serum IgG glycome composition was analyzed by hydrophilic interaction liquid chromatography with ultra-high-performance liquid chromatography approach.

Results:

The proportion of fucosylated glycans in total IgG glycans was 93.72% in the epilepsy patients, which was significantly lower than that in the control group (94.94%). A lower level of total monogalactosylated and digalactosylated glycans were observed in the epilepsy patients group (30.76 and 40.14%) than that in the controls (36.17 and 42.69%). There was no significant difference between the two groups in bisected GlcNAc glycans and sialylated glycans.

Conclusion:

The decrease of core fucosylation and galactosylation may promote the inflammatory reaction of the body and participate in the occurrence of epilepsy in children.

• Authors: Yuejin Li, Fengxue Shi, Guanglei Wang, Jian Lv, Haitao Zhang, Hao Jin, Xueyu Chen, Meng Wang, Peirui Li, Long Ji
• Journal: Frontiers in molecular neuroscience (Front Mol Neurosci) Vol. 15 Pg. 843897 ( 2022) ISSN: 1662-5099 [Print] Switzerland
• PMID: 35845609 (Publication Type: Journal Article)
• Copyright: Copyright © 2022 Li, Shi, Wang, Lv, Zhang, Jin, Chen, Wang, Li and Ji.