Abstract | BACKGROUND: METHODS: In the prospective, multicenter, observational registry study PANDEMIC (Pooled Analysis of Neurologic DisordErs Manifesting in Intensive care of COVID-19), we enrolled COVID-19 patients with neurologic manifestations admitted to 19 German intensive care units (ICU) between April 2020 and September 2021. We performed descriptive and explorative statistical analyses. Multivariable models were used to investigate factors associated with disorder categories and their underlying diagnoses as well as to identify predictors of outcome. RESULTS: Of the 392 patients included in the analysis, 70.7% (277/392) were male and the mean age was 65.3 (SD ± 3.1) years. During the study period, a total of 2681 patients with COVID-19 were treated at the ICUs of 15 participating centers. New neurologic disorders were identified in 350 patients, reported by these centers, suggesting a prevalence of COVID-19-associated neurologic disorders of 12.7% among COVID-19 ICU patients. Encephalopathy (46.2%; 181/392), cerebrovascular (41.0%; 161/392) and neuromuscular disorders (20.4%; 80/392) were the most frequent categories identified. Out of 35 cerebrospinal fluid analyses with reverse transcriptase PCR for SARS-COV-2, only 3 were positive. In-hospital mortality was 36.0% (140/389), and functional outcome (mRS 3 to 5) of surviving patients was poor at hospital discharge in 70.9% (161/227). Intracerebral hemorrhage (OR 6.2, 95% CI 2.5-14.9, p < 0.001) and acute ischemic stroke (OR 3.9, 95% CI 1.9-8.2, p < 0.001) were the strongest predictors of poor outcome among the included patients. CONCLUSIONS:
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Authors | Konstantinos Dimitriadis, Jan Meis, Hermann Neugebauer, Kristian Barlinn, Bernhard Neumann, Georg Gahn, Piergiorgio Lochner, Benjamin Knier, Sarah Lindemann, Kurt Wolfram Sühs, Kristina Szabo, Thomas Pfefferkorn, Ingo Schirotzek, Tobias Freilinger, Bassa Burc, Albrecht Günther, Matthias Wittstock, Patrick Schramm, Gernot Reimann, Jana Godau, Gabor Nagy, Fatima B Koenig, Fabian Essig, Hartwig Klinker, Christian Hartmann, Moritz L Schmidbauer, Tim Steinberg, Lora Lefterova, Christina Klose, Julian Bösel, IGNITE study group |
Journal | Critical care (London, England)
(Crit Care)
Vol. 26
Issue 1
Pg. 217
(07 16 2022)
ISSN: 1466-609X [Electronic] England |
PMID | 35842675
(Publication Type: Journal Article, Multicenter Study, Observational Study)
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Copyright | © 2022. The Author(s). |
Topics |
- Aged
- COVID-19
(complications, epidemiology)
- Cerebral Hemorrhage
(virology)
- Critical Illness
(epidemiology, therapy)
- Female
- Humans
- Intensive Care Units
- Ischemic Stroke
(virology)
- Male
- Middle Aged
- Nervous System Diseases
(virology)
- Pandemics
- Prospective Studies
- Registries
- SARS-CoV-2
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