Precuneus and insular hypoactivation during cognitive processing in first-episode psychosis: Systematic review and meta-analysis of fMRI studies.

Abstract

INTRODUCTION:

The neural correlates of the cognitive dysfunction in first-episode psychosis (FEP) are still unclear. The present review and meta-analysis provide an update of the location of the abnormalities in the fMRI-measured brain response to cognitive processes in individuals with FEP.

METHODS:

Systematic review and voxel-based meta-analysis of cross-sectional fMRI studies comparing neural responses to cognitive tasks between individuals with FEP and healthy controls (HC) according to PRISMA guidelines.

RESULTS:

Twenty-six studies were included, comprising 598 individuals with FEP and 567 HC. Individual studies reported statistically significant hypoactivation in the dorsolateral prefrontal cortex (6 studies), frontal lobe (8 studies), cingulate (6 studies) and insula (5 studies). The meta-analysis showed statistically significant hypoactivation in the left anterior insula, precuneus and bilateral striatum.

CONCLUSIONS:

While the studies tend to highlight frontal hypoactivation during cognitive tasks in FEP, our meta-analytic results show that the left precuneus and insula primarily display aberrant activation in FEP that may be associated with salience attribution to external stimuli and related to deficits in perception and regulation.

• Authors: Pau Soldevila-Matías, Anton Albajes-Eizagirre, Joaquim Radua, Gracián García-Martí, José M Rubio, Diana Tordesillas-Gutierrez, Inmaculada Fuentes-Durá, Aleix Solanes, Lydia Fortea, Dominic Oliver, Julio Sanjuán
• Journal: Revista de psiquiatria y salud mental (Rev Psiquiatr Salud Ment (Engl Ed)) 2022 Apr-Jun Vol. 15 Issue 2 Pg. 101-116 ISSN: 2173-5050 [Electronic] Spain
• PMID: 35840277 (Publication Type: Journal Article, Meta-Analysis, Review, Systematic Review)
• Copyright: Copyright © 2020 SEP y SEPB. Published by Elsevier España, S.L.U. All rights reserved.

Topics

• Cognition
• Cross-Sectional Studies
• Humans
• Magnetic Resonance Imaging
• Parietal Lobe
• Psychotic Disorders (diagnostic imaging, psychology)