Three new feruloyl glucuronopyranosyl glycerols from Eriocaulon buergerianum with their anti-fibrotic effects on hepatic stellate cells.

Abstract

Three new feruloyl glucuronopyranosyl glycerols, 1-O-α-D-(2'-feruloyl) glucuronopyranosyl glycerol (1), 1-O-α-D-(3'-feruloyl) glucuronopyranosyl glycerol (2), and 1-O-α-D-(4'-feruloyl) glucuronopyranosyl glycerol (3) were isolated and purified from the capitulum of Eriocaulon buergerianum Koern. Their structures were identified by spectroscopic and chemical methods. Molecular docking study showed that 1 is a potential inhibitor of TGF-β1 receptor. Bioassay results revealed that 1 exhibited strong inhibitory activity against the TGF-β-induced expression of α-smooth muscle actin (α-SMA) and fibronectin in human hepatic stellate LX-2 cells. The results in this study indicated that the new feruloyl glucuronopyranosyl glycerol 1 has preventive and therapeutic potentials against hepatic fibrosis.

• Authors: Yong Zhang, Hao Li, Zhijian Xu, Yulong Shi, Bo Li, Jia Li, Haji Akber Aisa, Yi Zang, Weiliang Zhu
• Journal: Natural product research (Nat Prod Res) Vol. 37 Issue 6 Pg. 956-966 (Mar 2023) ISSN: 1478-6427 [Electronic] England
• PMID: 35834727 (Publication Type: Journal Article)

Chemical References

• Glycerol

Topics

• Humans
• Hepatic Stellate Cells
• Glycerol (pharmacology, metabolism)
• Molecular Docking Simulation
• Liver Cirrhosis (drug therapy, pathology)
• Spectrum Analysis