[Efficacy of enteric lecithin (phosphatidylcholine) in the treatment of ulcerative colitis: a meta-analysis].

Abstract

BACKGROUND:

Phosphatidylcholine is an essential component of the intestinal mucus and serves as a protective shield against the ingress of bacteria from the stool. In the intestinal mucus of patients with ulcerative colitis, phosphatidylcholine is reduced by 70%, which makes the intestine susceptible to bacterial inflammation. Local application by administering enteric phosphatidylcholine could compensate for this deficiency.

METHOD:

A summary analysis of three clinical studies published until now with 160 included patients with ulcerative colitis was performed.

RESULTS AND CONCLUSION:

The meta-analysis showed that lecithin enriched with phosphatidylcholine and microencapsulated with Eudragit S-100 significantly improved the remission rate as well as the clinical and endoscopic picture. There was also an improvement in histology and quality of life. All parameters were significantly superior to placebo. The remission achieved was maintained significantly longer with enteric lecithin than with placebo. The side effect profile was identical to the placebo group, which is particularly important for the patients. In complementary medicine, phosphatidylcholine can be seen as protection for the intestines.

• Authors: Wolfgang Stremmel, Hüseyin Vural, Osman Evliyaoglu, Ralf Weiskirchen
• Journal: MMW Fortschritte der Medizin (MMW Fortschr Med) Vol. 164 Issue Suppl 7 Pg. 3-11 (07 2022) ISSN: 1613-3560 [Electronic] Germany
• Vernacular Title: Wirksamkeit von darmlöslichem Lecithin (Phosphatidylcholin) zur Behandlung der Colitis ulcerosa : Eine Metaanalyse.
• PMID: 35831742 (Publication Type: Journal Article, Meta-Analysis)
• Copyright: © 2022. Springer Medizin Verlag GmbH, ein Teil von Springer Nature.

Chemical References

• Lecithins

Topics

• Colitis, Ulcerative (drug therapy)
• Humans
• Lecithins (therapeutic use)
• Quality of Life
• Remission Induction