Abstract | BACKGROUND AND OBJECTIVES: METHODS: Using clinicopathologic data, immunofluorescence (IF) imaging, and whole-transcriptome analysis, 22 breast cancers (BCs) associated with Yo-PCD were characterized in terms of oncologic characteristics, genetic alteration of Yo antigens, differential gene expression profiles, and morphofunctional specificities of their in situ antitumor immunity by comparing them with matched control BCs. RESULTS: Yo-PCD BCs were invasive carcinoma of no special type, which early metastasized to lymph nodes. They overexpressed human epidermal growth factor receptor 2 (HER2) but were hormone receptor negative. All Yo-PCD BCs carried at least 1 genetic alteration (variation or gain in copy number) on CDR2L, encoding the main Yo antigen that was found aberrantly overexpressed in Yo-PCD BCs. Analysis of the differentially expressed genes found 615 upregulated and 54 downregulated genes in Yo-PCD BCs compared with HER2-driven control BCs without PCD. Ontology enrichment analysis found significantly upregulated adaptive immune response pathways in Yo-PCD BCs. IF imaging confirmed an intense immune infiltration with an overwhelming predominance of immunoglobulin G-plasma cells. DISCUSSION: These data confirm the role of genetic alterations of Yo antigens in triggering the immune tolerance breakdown but also outline a specific biomolecular profile in Yo-PCD BCs, suggesting a cancer-specific pathogenesis.
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Authors | Elise Peter, Isabelle Treilleux, Valentin Wucher, Emma Jougla, Alberto Vogrig, Daniel Pissaloux, Sandrine Paindavoine, Justine Berthet, Géraldine Picard, Véronique Rogemond, Marine Villard, Clémentine Vincent, Laurie Tonon, Alain Viari, Jérôme Honnorat, Bertrand Dubois, Virginie Desestret |
Journal | Neurology(R) neuroimmunology & neuroinflammation
(Neurol Neuroimmunol Neuroinflamm)
Vol. 9
Issue 5
(09 2022)
ISSN: 2332-7812 [Electronic] United States |
PMID | 35821104
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2022 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology. |
Chemical References |
- Antibodies, Neoplasm
- Autoantibodies
- Nerve Tissue Proteins
- anti-Yo autoantibodies
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Topics |
- Antibodies, Neoplasm
- Autoantibodies
- Breast Neoplasms
(complications, genetics)
- Female
- Humans
- Nerve Tissue Proteins
(genetics)
- Paraneoplastic Cerebellar Degeneration
(genetics)
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