Abstract | Objectives: Methods: Groups of CHD patients (n = 283) and healthy controls (n = 261) were involved in this study. R92H, V279F, and A379V polymorphisms of LP-PLA2 gene were confirmed using polymerase chain reaction (PCR) and direct DNA sequencing. These polymorphisms and their interaction were also analyzed as potential risk factors of CHD. Results: In this study population, the genotypes of R92H (GG, GA, and AA), V279F (CC, AC, and AA) and A379V (GG, GA, and AA) were studied. There was a significantly difference in frequencies of R92H between CHD patients and controls (P < 0.05). In contrast, no significant difference in frequencies of V279F and A379V existed between CHD patients and controls. Furthermore, R92H and A379V were in strong linkage disequilibrium. Conclusions: These results suggested that R92H polymorphism might contribute to increased risk of CHD.
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Authors | Sha Ma, Liangcai Ding, Mengdi Cai, Lu Chen, Bo Yan, Jian Yang |
Journal | Disease markers
(Dis Markers)
Vol. 2022
Pg. 9775699
( 2022)
ISSN: 1875-8630 [Electronic] United States |
PMID | 35818585
(Publication Type: Journal Article)
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Copyright | Copyright © 2022 Sha Ma et al. |
Chemical References |
- 1-Alkyl-2-acetylglycerophosphocholine Esterase
- PLA2G7 protein, human
|
Topics |
- 1-Alkyl-2-acetylglycerophosphocholine Esterase
(genetics)
- Coronary Disease
(genetics)
- Genotype
- Humans
- Polymorphism, Genetic
- Risk Factors
|