Abstract | BACKGROUND: METHODS: Fusing the transcriptional inhibitory domain KRAB with STAT3 successfully blocked the transcription activity of STAT3 in cancer cells without affecting its function in the mitochondria and lysosomes. RESULTS: the expression of KRAB-STAT3 fusion protein inhibited the growth of tumor cells. CONCLUSIONS:
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Authors | Yanqiong Chen, Wenting Zhang, Xiufeng Bai, Yi Liu |
Journal | BMC cancer
(BMC Cancer)
Vol. 22
Issue 1
Pg. 751
(Jul 10 2022)
ISSN: 1471-2407 [Electronic] England |
PMID | 35810312
(Publication Type: Journal Article)
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Copyright | © 2022. The Author(s). |
Chemical References |
- STAT3 Transcription Factor
- STAT3 protein, human
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Topics |
- Gene Expression Regulation
- Humans
- Male
- Neoplasms
(pathology)
- Neurodegenerative Diseases
- STAT3 Transcription Factor
(metabolism)
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