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Dissecting super-enhancer heterogeneity: time to re-examine cancer subtypes?

Abstract
The heterogeneity of transcriptional regulations by super-enhancers (SEs) is poorly understood in human cancers. Herein, we summarize a bioinformatics workflow for genome-wide SE profiling and identification of subtype-specific SEs and regulatory networks. Dissecting SE heterogeneity provides new insights into cancer biology and alternative therapeutic strategies for cancer precision medicine.
AuthorsTan Wu, Hao Huang, Xin Wang
JournalTrends in genetics : TIG (Trends Genet) Vol. 38 Issue 12 Pg. 1199-1203 (12 2022) ISSN: 0168-9525 [Print] England
PMID35803787 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2022 The Author(s). Published by Elsevier Ltd.. All rights reserved.
Topics
  • Humans
  • Regulatory Sequences, Nucleic Acid
  • Neoplasms (genetics)
  • Computational Biology
  • Gene Expression Regulation
  • Enhancer Elements, Genetic (genetics)

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