Abstract |
Hydrogen sulfide (H2S) induces acute and lethal toxicity at high concentrations. However, no specific antidotes for H2S poisoning have been approved. Liposomal methemoglobin (metHb@Lipo) was developed as an antidote for cyanide poisoning. As the toxic mechanism of H2S poisoning is the same as that of cyanide poisoning, metHb@Lipo could potentially be used as an antidote for H2S poisoning. In this study, we evaluated the antidotal efficacy of metHb@Lipo against H2S poisoning. Stopped-flow rapid-scan spectrophotometry clearly showed that metHb@Lipo scavenged H2S rapidly. Additionally, metHb@Lipo showed cytoprotective effects against H2S exposure in H9c2 cells by maintaining mitochondrial function. MetHb@Lipo treatment also improved the survival rate after H2S exposure in vivo, with the maintenance of cytochrome c oxidase activity and suppression of metabolic acidosis. Moreover, metHb@Lipo therapy maintained significant antidotal efficacy even after 1-year-storage at 4-37 °C. In conclusion, metHb@Lipo is a candidate antidote for H2S poisoning.
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Authors | Yuto Suzuki, Kazuaki Taguchi, Tomoko Kure, Yuki Enoki, Masaki Otagiri, Hiromi Sakai, Kazuaki Matsumoto |
Journal | Toxicology and applied pharmacology
(Toxicol Appl Pharmacol)
Vol. 450
Pg. 116159
(09 01 2022)
ISSN: 1096-0333 [Electronic] United States |
PMID | 35803436
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2022 Elsevier Inc. All rights reserved. |
Chemical References |
- Antidotes
- Cyanides
- Methemoglobin
- Hydrogen Sulfide
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Topics |
- Antidotes
(pharmacology, therapeutic use)
- Cyanides
- Humans
- Hydrogen Sulfide
(metabolism)
- Methemoglobin
(metabolism, pharmacology)
- Poisoning
(drug therapy)
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