To evaluate the efficacy and safety of
sodium oligomannate in the treatment of
Alzheimer's disease. Patients with mild-to-moderate AD were randomly divided into three groups, the scores of ADAS-Cog,
ADL, CIBIC-plus, NPI and CSDD were evaluated at the 0th, 12th, 24th, 36th and 48th weeks of medication. Comparing the mean scores of each scale in each cycle of each group. Using SPSS21.0 software for measurement data using t test, Chi-square test was used for counting data. A total of 72 patients with AD were included. The difference of CIBIC-plus score at week 12(P=0.007) and 24(P=0.005), ADAS-Cog scores (P=0.01) at week 24 in
GV-971 group was statistically significant compared with that in the control group. The CIBIC-plus score at week 24(P=0.01) and week 48 (P=0.04), CSDD scores at week 48(P=0.02) of
GV-971 group was statistically significant compared with that of
donepezil group. There were 2 cases of adverse reaction of increased stool frequency in
GV-971 (5.67%), and 2 cases of adverse reaction of
nausea in
donepezil group (8.33%), the difference was statistically significant.
GV-971 is as effective as
donepezil in the treatment of
Alzheimer's disease, and may even be better. It has good safety.