Abstract |
Background: Catheter-based thrombus removal (CBTR) reduces the risk of moderate to severe post-thrombotic syndrome (PTS) in patients with acute iliofemoral deep vein thrombosis (IF-DVT). However, the impact of concomitant popliteal DVT on clinical and duplex sonographic outcomes is unknown. Patients and methods: In this post-hoc analysis including the entire cohort of the randomized controlled BERNUTIFUL trial (48 patients), we compared clinical (incidence/severity of PTS assessed by Villalta score and revised venous clinical severity scores, rVCSS), disease-specific quality-of-life (QOL, CIVIQ-20 survey) and duplex sonographic outcomes (patency, reflux, post-thrombotic lesions) at 12 months follow-up between patients with IF-DVT with and without concomitant popliteal DVT treated by CBTR. Results: Overall, 48 IF-DVT patients were included (48% men, median age of 50 years), of whom 17 (35%) presented with popliteal DVT. At baseline, patients with popliteal DVT were older, had a higher body mass index and more important leg swelling. At 12 months, freedom from PTS (93% vs 87%, P=0.17), median total Villalta score (1 vs 1.5; P=0.46), rVCSS (2 vs 1.5, P=0.5) and disease-specific QOL (24 points vs 24 points, P=0.72) were similar between patient with and without popliteal DVT, respectively. Duplex sonographic outcomes were similar, except for more frequent popliteal post-thrombotic lesions and reflux (P=0.02) in patients with popliteal DVT. Conclusions: Relevant clinical outcomes 1 year after successful CBTR were favorable, regardless of the presence or absence of concomitant popliteal DVT. However, post-thrombotic popliteal vein lesions and reflux are more frequent in IF-DVT patients with popliteal involvement. Their impact on long-term outcomes remains to be investigated.
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Authors | Vincent Frey, Tim Sebastian, Stefano Barco, David Spirk, Daniel Hayoz, Daniel Périard, Nils Kucher, Daniel Betticher, Rolf P Engelberger |
Journal | VASA. Zeitschrift fur Gefasskrankheiten
(Vasa)
Vol. 51
Issue 5
Pg. 282-290
(Sep 2022)
ISSN: 0301-1526 [Print] Switzerland |
PMID | 35774017
(Publication Type: Journal Article, Randomized Controlled Trial)
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Topics |
- Female
- Femoral Vein
(diagnostic imaging)
- Humans
- Iliac Vein
(diagnostic imaging)
- Male
- Middle Aged
- Popliteal Vein
(diagnostic imaging, pathology)
- Postthrombotic Syndrome
(etiology, therapy)
- Quality of Life
- Thrombolytic Therapy
(adverse effects)
- Treatment Outcome
- Venous Thrombosis
(complications, diagnostic imaging, therapy)
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