Cutaneous melanocytic tumor with CRTC1::TRIM11 fusion and prominent epidermal involvement: A case report.

Abstract

Cutaneous melanocytic tumor with CRTC1::TRIM11 fusion (CMCT) is a recently described entity with only 13 cases reported in the literature. Histopathologically, the neoplasm consists of atypical epithelioid to spindled cells that form a well-circumscribed nodule usually confined to the dermis and subcutis with cytological features including large vesicular nuclei with prominent nucleoli and abundant eosinophilic cytoplasm. Immunohistochemistry shows variable expressivity of melanocytic markers. Currently, there are limited data regarding long-term outcomes of this newly described entity. Most cases have done well, but there is one case reported with an adverse event. Hence, further studies are needed to accurately classify this tumor. Definitive diagnosis is made by laboratory evidence of CMCT. Herein, we report the first case of CMCT with epidermal involvement in the youngest patient known to be affected to date.

• Authors: Blake E Vest, Christina L Harview, Vincent Liu, Brian L Swick, Kristen G Berrebi, Shantel Olivares, Mary S Stone, Michael R Sargen, Pedram Gerami
• Journal: Journal of cutaneous pathology (J Cutan Pathol) Vol. 49 Issue 12 Pg. 1025-1030 (Dec 2022) ISSN: 1600-0560 [Electronic] United States
• PMID: 35751643 (Publication Type: Case Reports)
• Copyright: © 2022 The Authors. Journal of Cutaneous Pathology published by John Wiley & Sons Ltd.

Chemical References

• 1-cyclohexyl-3-(2-(4-morpholinyl)ethyl)carbodiimide
• Transcription Factors
• Biomarkers, Tumor
• CRTC1 protein, human
• TRIM11 protein, human
• Tripartite Motif Proteins
• Ubiquitin-Protein Ligases

Topics

• Humans
• Skin Neoplasms (genetics, pathology)
• Gene Fusion
• Transcription Factors (genetics)
• Melanocytes (pathology)
• Biomarkers, Tumor
• Tripartite Motif Proteins (genetics)
• Ubiquitin-Protein Ligases (genetics)