Intracranial Hypertension in a Transgender Man.

Abstract

Objective:

Case description of recurrent idiopathic intracranial hypertension (IIH) in a transgender man on gender-affirming hormone therapy.

Methods:

Case report.

Results:

A 24-year-old transmasculine patient (assigned female at birth), with a body mass index (BMI) of 37.3, presented with headaches, transient visual obscurations (TVOs), pulsatile tinnitus, Frisén 5 papilledema, and scotomas. He was diagnosed with IIH after normal magnetic resonance imaging (MRI) and magnetic resonance venogram (MRV), an elevated opening pressure of 27 cm water, and normal cerebrospinal fluid studies. IIH resolved with acetazolamide and optic nerve sheath fenestration (ONSF). He then started gender-affirming testosterone therapy and was on this for 20 months when his headaches, pulsatile tinnitus, TVOs, and Frisén 3 papilledema recurred at a BMI of 31. Brain MRI and MRV were normal. Opening pressure was elevated at 31 cm. water. Acetazolamide 4 g/day did not improve the papilledema, thus a left ONSF was repeated resulting in eventual resolution of the IIH.

Discussion:

Several reports have been published of IIH development in patients receiving testosterone therapy. Hormone prescribers for gender affirmation may wish to screen for visual loss and optic nerve edema in patients undergoing testosterone therapy, which may also stimulate appetite weight gain.

• Authors: Kasim Qureshi, Shakaib Qureshi, Adam Hassan, Aileen Antonio
• Journal: Neurology. Clinical practice (Neurol Clin Pract) Vol. 12 Issue 3 Pg. 275-277 (Jun 2022) ISSN: 2163-0402 [Print] United States
• PMID: 35747542 (Publication Type: Journal Article)
• Copyright: © 2022 American Academy of Neurology.