The burden of illness of patients with paroxysmal nocturnal haemoglobinuria receiving C5 inhibitors in France, Germany and the United Kingdom: Patient-reported insights on symptoms and quality of life.

Abstract

OBJECTIVES:

To assess the clinical, humanistic and economic burden of paroxysmal nocturnal haemoglobinuria (PNH) among C5 inhibitor (C5i)-treated patients with PNH.

METHODS:

This was a web-based, cross-sectional survey (01FEB2021-31MAR2021) of adults with PNH treated with eculizumab (France, Germany, United Kingdom) or ravulizumab (Germany). Self-reported outcomes included: patient characteristics; patient-reported symptoms; and standardised patient-reported outcomes (e.g. Functional Assessment of Chronic Illness Therapy [FACIT]-Fatigue, European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 [EORTC QLQ-C30]).

RESULTS:

Among 71 included patients, 98.6% were C5i-treated for ≥3 months (88.7% ≥12 months); among those with self-reported haemoglobin (Hb) levels (n = 63), most (85.7%) were anaemic (defined as ≤12.0 g/dL). Fatigue was the most common symptom at both diagnosis (73.2%) and survey time (63.4%); there were no statistically significant differences in symptom prevalence between treatment subgroups (eculizumab vs. ravulizumab). Total FACIT-Fatigue and EORTC QLQ-C30 scores were substantially lower than European general population references, but there were no statistically significant differences between treatment subgroups. Hb-level subgroups (<10.5 g/dL vs. ≥10.5 d/dL) followed similar trends for all measures, with few significant subgroup differences.

CONCLUSIONS:

Results suggest that there remains a considerable burden and unmet need among C5i-treated patients with PNH that requires improved therapies.

• Authors: Jens Panse, Flore Sicre de Fontbrune, Pascale Burmester, Maria Piggin, Joana E Matos, Halley Costantino, Koo Wilson, Zalmai Hakimi, Jameel Nazir, Renaud Desgraz, Jesse Fishman, Emmelie Persson, Austin Kulasekararaj
• Journal: European journal of haematology (Eur J Haematol) Vol. 109 Issue 4 Pg. 351-363 (Oct 2022) ISSN: 1600-0609 [Electronic] England
• PMID: 35746830 (Publication Type: Journal Article)
• Copyright: © 2022 The Authors. European Journal of Haematology published by John Wiley & Sons Ltd.

Topics

• Adult
• Cost of Illness
• Cross-Sectional Studies
• Fatigue (drug therapy, epidemiology, etiology)
• Germany (epidemiology)
• Hemoglobinuria, Paroxysmal (complications, diagnosis, drug therapy)
• Humans
• Patient Reported Outcome Measures
• Quality of Life