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The combined effect between BDNF genetic polymorphisms and exposure to metals on the risk of Chinese dyslexia.

Abstract
BDNF gene has been implicated in the development of cognition and language. Meanwhile, exposure to metals might interact with BDNF gene to increase the risk of neurodevelopmental disorders. The present study aimed to explore the association between BDNF genetic polymorphisms and dyslexic risk and examine whether BDNF polymorphisms would interact with metal exposures, jointly contributing to dyslexia. Among a case-control study composed of 238 children with dyslexia and 228 healthy controls, the BDNF genetic polymorphisms were genotyped by the Sequenom MassARRAY system, and the exposure to eight metals, such as lead (Pb), mercury (Hg) and copper (Cu), were measured using an inductively coupled plasma-mass spectrometer (ICP-MS). Multivariable logistic regression models were used to assess the adjusted odds ratios (ORs) and 95% confidence interval (CI) of dyslexia. After multivariate adjustment, significant associations of dyslexic risk with rs6265 polymorphisms of the BDNF gene were observed (OR = 1.99; 95% CI: 1.15-3.44). Furthermore, exposure to Cu could interact with rs6265 to increase the risk of dyslexia (P interaction = 0.045). High-Cu children with the rs6265 TT genotype were more likely to have dyslexia compared with low-Cu children carrying CC + CT genotypes (OR = 3.19; 95% CI: 1.38-7.39). The findings of this study suggested that the polymorphism of rs6265 in BDNF gene could interact with Cu exposure to increase the occurrence of dyslexia.
AuthorsKaiheng Zhu, Qi Liu, Xinyan Xie, Qi Jiang, Yanan Feng, Pei Xiao, Xiaoqian Wu, Ranran Song
JournalEnvironmental pollution (Barking, Essex : 1987) (Environ Pollut) Vol. 308 Pg. 119640 (Sep 01 2022) ISSN: 1873-6424 [Electronic] England
PMID35718045 (Publication Type: Journal Article)
CopyrightCopyright © 2022 Elsevier Ltd. All rights reserved.
Chemical References
  • Brain-Derived Neurotrophic Factor
  • Metals
  • BDNF protein, human
Topics
  • Brain-Derived Neurotrophic Factor (genetics)
  • Case-Control Studies
  • Child
  • China (epidemiology)
  • Dyslexia (epidemiology)
  • Genotype
  • Humans
  • Language
  • Metals (adverse effects)
  • Polymorphism, Single Nucleotide

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