Transforming growth factor-β signalling pathway in tendon healing.

Abstract

Transforming growth factor-β(TGF-β) plays an important but diverse role in tendon injuries, such as collagen synthesis, cell proliferation, cell differentiation, and cell adhesion, leading to tendon healing and tendon fibrosis. In the well-known canonical TGF-β signalling pathway, TGF-β activates Smad signalling through its two cell surface receptors, which leads to Smad-mediated transcriptional regulation and is also regulated by inhibitory Smads, forming a negative feedback regulatory pathway. In the context of the canonical TGF-β signalling mechanism mediated by Smad, the activated receptors also send signals through other signal transducers, which in the backdrop of TGF-β signaling are collectively known as non-Smad signalling pathways. Activated TGF-β binds to the receptor and acts through these signalling pathways. Understanding the mechanism of the TGF-β signalling pathway and its role in tendon repair is of great significance for targeting the TGF-β signalling pathway to accelerate tendon healing and reduce tendon fibrosis.

• Authors: Yujie Li, Xinyue Liu, Xueli Liu, Yuanqiu Peng, Bin Zhu, Sheng Guo, Chenglong Wang, Dingxuan Wang, Sen Li
• Journal: Growth factors (Chur, Switzerland) (Growth Factors) Vol. 40 Issue 3-4 Pg. 98-107 (08 2022) ISSN: 1029-2292 [Electronic] England
• PMID: 35707986 (Publication Type: Journal Article, Review)

Chemical References

• Smad Proteins
• Transforming Growth Factor beta
• Transforming Growth Factor beta1
• Transforming Growth Factors

Topics

• Fibrosis
• Humans
• Signal Transduction (physiology)
• Smad Proteins (metabolism)
• Tendons (metabolism)
• Transforming Growth Factor beta (metabolism)
• Transforming Growth Factor beta1
• Transforming Growth Factors (metabolism)