Abstract | BACKGROUND AND OBJECTIVE: METHODS: Our study used a self-controlled, before-and-after cohort design to assess the effectiveness of TIV and PPSV23 in COPD patients. Patients were recruited from hospitals in Tangshan City, Hebei Province, China. Subjects self-selected into one of the three vaccination schedules: TIV group, PPSV23 group and TIV& PPSV23 group. We used a physician-completed, medical record-verified questionnaire to obtain data on acute exacerbations of COPD (AECOPD), pneumonia and related hospitalization. Vaccine effectiveness was determined by comparing COPD outcomes before and after vaccination, controlling for potential confounding using Cox regression. RESULTS: We recruited 474 COPD patients, of whom 109 received TIV, 69 received PPSV23 and 296 received TIV and PPSV23. Overall effectiveness for preventing AECOPD, pneumonia and related hospitalization were respectively 70%, 59% and 58% in the TIV group; 54%, 53% and 46% in the PPSV23 group; and 72%, 73% and 69% in the TIV& PPSV23 group. The vaccine effectiveness without COVID-19 non- pharmaceutical intervention period were 84%, 77% and 88% in the TIV group; 63%, 74% and 66% in the PPSV23 group; and 82%, 83% and 91% in the TIV& PPSV23 group. CONCLUSION:
Influenza vaccination and PPSV23 vaccination, separately and together, can effectively reduce the risk of AECOPD, pneumonia and related hospitalization. Effectiveness for preventing AECOPD was the greatest.
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Authors | Yan Li, Pingshu Zhang, Zhijie An, Chenyan Yue, Yamin Wang, Yunqiu Liu, Xiaodong Yuan, Ying Ma, Keli Li, Zundong Yin, Liye Wang, Huaqing Wang |
Journal | Respirology (Carlton, Vic.)
(Respirology)
Vol. 27
Issue 10
Pg. 844-853
(10 2022)
ISSN: 1440-1843 [Electronic] Australia |
PMID | 35705329
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2022 Asian Pacific Society of Respirology. |
Chemical References |
- Influenza Vaccines
- Pneumococcal Vaccines
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Topics |
- COVID-19
- Humans
- Influenza Vaccines
(therapeutic use)
- Influenza, Human
(epidemiology, prevention & control)
- Pneumococcal Infections
(chemically induced, prevention & control)
- Pneumococcal Vaccines
(therapeutic use)
- Pneumonia
(chemically induced)
- Pneumonia, Pneumococcal
(epidemiology, prevention & control)
- Pulmonary Disease, Chronic Obstructive
(complications)
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