Does the rubella immunoglobulin G affect the severity of COVID- 19?  : Rubella immunoglobulin G and COVID- 19.

Abstract

OBJECTIVE & AIM:

The coronavirus disease, so far (COVID-19) has brought about millions of infections and fatalities throughout the world. Our aim was to determine the correlation between rubella IGG titers with the severity COVID-19.  MATERIALS & METHODS: This study was conducted among COVID-19 confirmed patients over 18 years of age. The disease severity levels were categorized by WHO interim guidance. The rubella-specific IgG antibody-titer spectrum was measured (within first 48 h of hospitalization) by enzyme-linked immunosorbent assay (ELISA).

RESULT:

In a study of 46 inpatients with varying COVID-19 disease severity (mild, moderate, severe, and critical), we observed a negative correlation between rubella IgG antibody titers and COVID-19 severity (P-Value = 0.017), There was an interaction between COVID-19 vaccination history and rubella IGG on severity COVID-19 (P-Value = 0.0015). There was an interaction between age group under 44 years (including national measles- rubella (MR) vaccination in Iran) and rubella IGG titers on severity COVID-19 too (p-value = 0.014).

CONCLUSION:

In conclusion, MR vaccination seems to have a positive effect in reducing the severity of the disease, emphasizing that, the important and separate effect of the IGG rubella (due to natural or extrinsic immunity) titers is determining.

• Authors: Leyla Sahebi, Mohsen Hosseini, Alireza Abdollahi, Nahid Farrokhzad, Samrand Fattah Ghazi, Farzaneh Samaei Noroozi, Fereshteh Ghiasvand
• Journal: BMC microbiology (BMC Microbiol) Vol. 22 Issue 1 Pg. 156 (06 11 2022) ISSN: 1471-2180 [Electronic] England
• PMID: 35690730 (Publication Type: Journal Article)
• Copyright: © 2022. The Author(s).

Chemical References

• Antibodies, Viral
• COVID-19 Vaccines
• Immunoglobulin G

Topics

• Adolescent
• Adult
• Antibodies, Viral
• COVID-19
• COVID-19 Vaccines
• Enzyme-Linked Immunosorbent Assay
• Humans
• Immunoglobulin G
• Rubella