Atezolizumab combined with chemotherapy in the first-line treatment of extensive-stage small cell lung cancer: a real-life data of the Turkish Oncology Group.

Abstract

PURPOSE:

Atezolizumab has been shown to be effective and safe in randomized trial in the first-line treatment of extensive-stage small cell lung cancer (SCLC). However, there are limited real-life data on atezolizumab. In this study, we aimed to determine the real-life efficacy and safety of atezolizumab combined with chemotherapy in the first-line treatment of extensive-stage SCLC.

METHODS:

This trial is a retrospective multicenter study of the Turkish Oncology Group, which included extensive-stage SCLC patients who received atezolizumab combined with chemotherapy in a first-line treatment. The characteristics of the patients, treatment and response rates, and PFS and OS are presented. Factors associated with PFS and OS were analyzed by univariate and multivariate analysis.

RESULTS:

A total of 213 patients at the 30 oncology centers were included. The median number of chemotherapy cycle was 5 (1-8) and atezolizumab cycle was 7 (1-32). After median 11.9 months of follow-up, median PFS and OS was 6.8 months (95%CI 5.7-7.8), and 11.9 months (95%CI 11-12.7), respectively. The ORR was 61.9%. ECOG-PS (p = 0.002) and number of metastatic sites (p = 0.001) were associated with PFS and pack-year of smoking (p = 0.05), while ECOG-PS (p = 0.03) and number of metastatic sites (p = 0.001) were associated with OS. Hematological side effects were common and toxicities were manageable.

CONCLUSION:

This real-life data confirm the efficacy and safety of atezolizumab in combination with chemotherapy in first-line treatment of extensive-stage SCLC.

• Authors: Mustafa Gürbüz, Yasin Kutlu, Erman Akkuş, Elif Berna Köksoy, Naziyet Köse, Bala Başak Öven, Başak Oyan Uluç, Atike Gökçen Demiray, Dilek Erdem, Bilgin Demir, Nazım Serdar Turhal, Necdet Üskent, Sinem Akbaş, Fatih Selçukbiricik, Ali İnal, Ahmet Bilici, Ömer Fatih Ölmez, Devrim Çabuk, Çağlar Ünal, Mutlu Hızal, Mehmet Ali Nahit Şendur, Mustafa Korkmaz, Nuri Karadurmuş, İsmail Ertürk, Sema Sezgin Göksu, Ali Murat Tatlı, Deniz Can Güven, Saadettin Kılıçkap, Nail Paksoy, Adnan Aydıner, Havva Yeşil Çınkır, Özlem Özkul, Akın Öztürk, Sevinç Ballı, Yasemin Kemal, Atike Pınar Erdoğan, Özlem Er, Perran Fulden Yumuk, Ahmet Demirkazık
• Journal: Journal of cancer research and clinical oncology (J Cancer Res Clin Oncol) Vol. 148 Issue 12 Pg. 3547-3555 (Dec 2022) ISSN: 1432-1335 [Electronic] Germany
• PMID: 35689097 (Publication Type: Multicenter Study, Journal Article)
• Copyright: © 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

Chemical References

• atezolizumab
• Antibodies, Monoclonal, Humanized

Topics

• Humans
• Small Cell Lung Carcinoma (drug therapy, pathology)
• Lung Neoplasms (pathology)
• Antineoplastic Combined Chemotherapy Protocols (adverse effects)
• Antibodies, Monoclonal, Humanized (adverse effects)