Sustained suppression of enterohepatic circulation of mycophenolic acid by antimicrobial-associated diarrhea in a kidney transplant recipient with Crohn's disease: A case report.

Abstract

Mycophenolic acid (MPA) undergoes enterohepatic circulation. A kidney transplant patient on mycophenolate mofetil was treated with tazobactam/piperacillin for pyelonephritis, and developed antimicrobial-associated diarrhea. Consequently, the MPA trough level decreased by approximately 90%. Furthermore, it took approximately a month for the MPA level to normalize even after diarrhea had resolved.

• Authors: Ryota Tanaka, Asami Matsumoto, Ryosuke Tatsuta, Tadasuke Ando, Toshitaka Shin, Hiromitsu Mimata, Hiroki Itoh
• Journal: Clinical case reports (Clin Case Rep) Vol. 10 Issue 6 Pg. e05914 (Jun 2022) ISSN: 2050-0904 [Print] England
• PMID: 35677857 (Publication Type: Case Reports)
• Copyright: © 2022 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd.