Progressive White Matter Injury in Preclinical Dutch Cerebral Amyloid Angiopathy.

Abstract

Autosomal-dominant, Dutch-type cerebral amyloid angiopathy (D-CAA) offers a unique opportunity to develop biomarkers for pre-symptomatic cerebral amyloid angiopathy (CAA). We hypothesized that neuroimaging measures of white matter injury would be present and progressive in D-CAA prior to hemorrhagic lesions or symptomatic hemorrhage. In a longitudinal cohort of D-CAA carriers and non-carriers, we observed divergence of white matter injury measures between D-CAA carriers and non-carriers prior to the appearance of cerebral microbleeds and >14 years before the average age of first symptomatic hemorrhage. These results indicate that white matter disruption measures may be valuable cross-sectional and longitudinal biomarkers of D-CAA progression. ANN NEUROL 2022;92:358-363.

• Authors: Zahra Shirzadi, Wai-Ying W Yau, Stephanie A Schultz, Aaron P Schultz, Matthew R Scott, Maged Goubran, Parisa Mojiri-Forooshani, Nelly Joseph-Mathurin, Kejal Kantarci, Greg Preboske, Marieke J H Wermer, Clifford Jack, Tammie Benzinger, Kevin Taddei, Hamid R Sohrabi, Reisa A Sperling, Keith A Johnson, Randall J Bateman, Ralph N Martins, Steven M Greenberg, Jasmeer P Chhatwal, DIAN Investigators
• Journal: Annals of neurology (Ann Neurol) Vol. 92 Issue 3 Pg. 358-363 (09 2022) ISSN: 1531-8249 [Electronic] United States
• PMID: 35670654 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
• Copyright: © 2022 American Neurological Association.

Topics

• Cerebral Amyloid Angiopathy (diagnostic imaging, pathology)
• Cerebral Hemorrhage (diagnostic imaging, pathology)
• Cross-Sectional Studies
• Hemorrhage (pathology)
• Humans
• Magnetic Resonance Imaging
• Neuroimaging
• White Matter (diagnostic imaging, pathology)