Monoglycocalix[4]arene-based nanoparticles for tumor selective drug delivery via GLUT1 recognition of hyperglycolytic cancers.

Abstract

We have developed a new strategy of tumor-specific glucose transporter (GLUT)-mediated selective drug delivery using amphiphilic fluorescent monoglycocalix[4]arene in docetaxel (DTX) encapsulated nanoparticles (NPs) that leads to significant improvement in cytotoxic activity against a panel of human cancer cells. The fluorescent tracer conjugation in the calixarene enables the self-probed tumor targeting analysis and makes the system potentially suitable for tumor diagnostic imaging.

• Authors: Lijuan Zhang, Shengnan Liu, Yang Li, Min Liang, Hongxia Zhao, Wensheng Yang
• Journal: Organic & biomolecular chemistry (Org Biomol Chem) Vol. 20 Issue 24 Pg. 4884-4887 (06 22 2022) ISSN: 1477-0539 [Electronic] England
• PMID: 35670433 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• Drug Carriers
• Glucose Transporter Type 1
• Docetaxel

Topics

• Antineoplastic Agents (pharmacology)
• Cell Line, Tumor
• Docetaxel
• Drug Carriers
• Drug Delivery Systems (methods)
• Glucose Transporter Type 1
• Humans
• Nanoparticles
• Neoplasms (drug therapy)