Tumor-triggered targeting ammonium bicarbonate liposomes for tumor multimodal therapy.

Abstract

Tumor-triggered targeting ammonium bicarbonate (TTABC) liposomes were proposed to improve the uptake of ammonium bicarbonate (ABC) liposomes in tumor cells and retain their long circulation in vivo in our previous study. However, it must be solved how to precisely release the loaded drugs of the TTABC liposomes into tumor cells. In addition, synergistic multimodal therapy could result in better tumor treatment outcomes than monomodal chemotherapy. In the research, we prepared indocyanine green (ICG) and doxorubicin (DOX) encapsulated TTABC liposomes (ICG&DOX@TTABC) to achieve near-infrared (NIR) light-controlled chemo/photothermal/photodynamic multimodal therapy guided by fluorescence and photothermal imaging. In vitro and vivo studies show that ICG&DOX@TTABC can specifically accumulate in tumor tissues, effectively transform NIR light into local thermo-therapy, and have excellent anti-tumor ability without obvious side effects. ICG&DOX@TTABC could be promising for fluorescence and photothermal imaging-guided chemo/photothermal/photodynamic tumor treatment.

• Authors: Quan-Bing Chen, Mei-Hua Shen, Xiao-He Ren, Shuai Zhu, Jin-Ting Shang, Wei Liu, Zhao-Wei Zhang, Zhi-Jun Dong, Hua-Zhi Gu, Xian-Zheng Zhang, Qiong Yuan, Tao Zou
• Journal: Journal of materials chemistry. B (J Mater Chem B) Vol. 10 Issue 27 Pg. 5154-5164 (07 13 2022) ISSN: 2050-7518 [Electronic] England
• PMID: 35666635 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Bicarbonates
• Liposomes
• ammonium bicarbonate
• Doxorubicin
• Indocyanine Green

Topics

• Bicarbonates
• Combined Modality Therapy
• Doxorubicin
• Humans
• Indocyanine Green (pharmacology, therapeutic use)
• Liposomes (therapeutic use)
• Neoplasms (drug therapy)
• Phototherapy (methods)