Abstract | Objective: To investigate the influencing factors of transcatheter arterial chemoembolization (TACE) on patients with hepatocellular carcinoma (HCC) for tumor response (complete and partial response, CR + PR). Methods: This research conducted a retrospective study of the hospital charts of patients treated with TACE successfully renewed from October 2014 to December 2015 at Sun Yat-sen University Cancer Center (Guangzhou, China). Univariate analysis (Chi-square test and repeated-measures ANOVA) selected nine influential tumor response factors from 22 core factors. The nine variables were included in a forward multiple logistic regression model predicting patients treated with TACE to achieve tumor response. Overall survival was calculated using the Kaplan-Meier method. Results: Data of 277 of 282 patients were included in the analysis. Nine variables were analyzed by univariate analysis and independently associated with tumor response ( tumor capsule integrity, nausea and vomiting, microwave ablation, liver dysfunction, the absolute value of lymphocyte (LYM), alpha-fetoprotein, and gamma-glutamyl transpeptidase (GGT). By multivariate analysis, GGT (odds ratio [OR] =0.996), liver dysfunction (OR = 0.395), combined with microwave ablation (OR = 0.503), and tumor capsule integrity (OR = 1.894) were the significant predictors of the tumor response group compared with the standard deviation group (P < 0.05). Conclusions: This study suggests that TACE combined with ablation on patients with complete tumor capsules may have a better prognosis in tumor response and OS; additionally, liver dysfunction and nausea and vomiting were the independent predictors of tumor response.
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Authors | Hongyan Shao, Juan Deng, Luping Xie, Qiwen Zheng, Bihui Zou, Jun Deng, Tianqi Zhang, Jingjing He |
Journal | Journal of cancer research and therapeutics
(J Cancer Res Ther)
Vol. 18
Issue 2
Pg. 560-566
(Apr 2022)
ISSN: 1998-4138 [Electronic] India |
PMID | 35645128
(Publication Type: Journal Article)
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Topics |
- Carcinoma, Hepatocellular
(therapy)
- Chemoembolization, Therapeutic
(methods)
- Humans
- Liver Neoplasms
(therapy)
- Retrospective Studies
- Treatment Outcome
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