Robust antibody response after a third BNT162b2 vaccine compared to the second among immunocompromised and healthy individuals, a prospective longitudinal cohort study.

Abstract

PURPOSE:

As protection from COVID-19 following two doses of the BNT162b2 vaccine showed a time dependent waning, a third (booster) dose was administrated. This study aims to compare the antibody response following the third dose versus the second and to evaluate post-booster seroconversion.

METHODS:

A prospective observational study conducted in Maccabi Healthcare Services. Serial SARS-CoV-2 Spike IgG tests, 1,2,3 and 6 months following the second vaccine dose and one month following the third were obtained. Neutralizing antibody levels were measured in a subset of participants. Per individual SARS-CoV-2 Spike IgG titer ratios were calculated one month after the booster administration compared to titers one month following the second dose and prior to booster.

RESULTS:

Among 110 participants,56 (51%) were women. Mean age was 61.7 ± 1.9 years and 66 (60%) were immunocompromised. One month after third dose, IgG titers were induced 7.83 (95 %CI 5.25-11.67) folds and 2.40 (95 %CI 1.90-3.03) folds compared to one month after the second, in the immunocompromised and immunocompetent groups, respectively. Of the 17 immunocompromised participants who were seronegative after the second dose, 4 (24%) became seropositive following the third. Comparing the titers prior to the third dose, an increase of 50.7 (95 %CI 32.5-79.1) fold in the immunocompromised group and 25.7 (95 %CI 19.1-34.7) fold in and immunocompetent group, was observed.

CONCLUSION:

A third BNT162b2 vaccine elicited robust humoral response, superior to the response observed following the second, among immunocompetent and immunocompromised individuals.

• Authors: Shirley Shapiro Ben David, Barak Mizrahi, Daniella Rahamim-Cohen, Lia Supino-Rosin, Arnon Shahar, Sharon Hermoni-Alon, Ariela Fremder Sacerdote, Angela Irony, Rachel Lazar, Nir Kalkstein, Yaniv Lustig, Victoria Indenbaum, Daniel Landsberger, Miri Mizrahi-Reuveni, Shirley Shapira
• Journal: Vaccine (Vaccine) Vol. 40 Issue 30 Pg. 4038-4045 (06 26 2022) ISSN: 1873-2518 [Electronic] Netherlands
• PMID: 35641358 (Publication Type: Journal Article, Observational Study)
• Copyright: Copyright © 2022 Elsevier Ltd. All rights reserved.

Chemical References

• Antibodies, Viral
• Immunoglobulin G
• Vaccines
• BNT162 Vaccine

Topics

• Antibodies, Viral
• Antibody Formation
• BNT162 Vaccine
• COVID-19 (prevention & control)
• Female
• Humans
• Immunoglobulin G
• Longitudinal Studies
• Male
• Middle Aged
• Prospective Studies
• SARS-CoV-2
• Vaccines