Hypoglycemic, Hypolipidemic, and Anti-Inflammatory Effects of Beta-Pinene in Diabetic Rats.

Abstract

Background:

Diabetes is a metabolic disease linked to multiple comorbidities, such as low-grade inflammation. β-pinene, a monoterpene commonly found in aromatic plants, is endowed with anti-inflammatory effect and this fact lead us to investigate the possible hypoglycemic, hypolipidemic and anti-inflammatory effects of the monoterpene in the alloxan-induced diabetes experimental model.

Methods:

Male Wistar rats (200-250 g) were treated orally with β-pinene (25, 50, 100, and 200 mg/kg) or glibenclamide (5 mg/kg), for seven consecutive days. Diabetes was induced by alloxan (40 mg/kg) through the penile vein. On the seventh day of treatment, blood samples were collected for biochemical analysis. The anti-inflammatory effect of β-pinene was evaluated using the carrageenan-induced paw edema model, followed by the carrageenan-induced peritonitis.

Results:

The treatment with β-pinene decreased plasma glucose, triglyceride, VLDL, LDL, and HDL levels, when compared to those of the control group. In addition, the association β-pinene 10 mg/kg + glibenclamide 2 mg/kg significantly decreased blood glucose, total cholesterol, and triglyceride level. Finally, oral treatment with β-pinene reduced carrageenan-induced paw edema and leukocyte migration in the peritoneum. Taken together, our results indicate that β-pinene shows hypoglycemic and hypolipemic effects, which may involve some common mechanisms of glibenclamide. Besides, the monoterpene presented an anti-inflammatory action in diabetic rats that needs further investigation in order to clarify such effect and its correlation with the alterations observed in plasma parameters of β-pinene-treated diabetic rats.

• Authors: Enaide Soares Santos, Geraldo Lucas Abrantes Coelho, Yan Kauê Saraiva Fontes Loula, Bárbara Lourenço Saraiva Landim, Cícera Norma Fernandes Lima, Sara Tavares de Sousa Machado, Maria Janice Pereira Lopes, Acléssia Damiana Soares Gomes, José Galberto Martins da Costa, Irwin Rose Alencar de Menezes, Henrique Douglas Melo Coutinho, Bonglee Kim, Cícero Francisco Bezerra Felipe, Samya de Araújo Neves, Marta Regina Kerntopf
• Journal: Evidence-based complementary and alternative medicine : eCAM (Evid Based Complement Alternat Med) Vol. 2022 Pg. 8173307 ( 2022) ISSN: 1741-427X [Print] United States
• PMID: 35620400 (Publication Type: Journal Article)
• Copyright: Copyright © 2022 Enaide Soares Santos et al.