Five glycosylated phenolic derivatives from the bark of Ilex rotunda Thunb. and their anti-inflammatory activities.

Abstract

Five new glycosylated phenolic derivatives, rotundosides A-E (1-5), and three known glycosides (6-8) were isolated from the 95% alcohol extract of the bark of Ilex rotunda. Their structures were elucidated by extensive spectroscopic analysis and comparison with the literature data. All new compounds possessed a [5-O-(E)-caffeoyl]-β-D-apiofuranosyl-(1→6)-β-D-glucopyranosyl group. The anti-inflammatory properties of all isolated compounds were evaluated using a modified nitric oxide (NO) production in lipopolysaccharide (LPS)-induced leukemia cells in mouse macrophage (RAW264.7) method. Compound 8, dracunculifoside H, showed significant anti-inflammatory activity in vitro.

• Authors: Shou Peng, Tong Chen, Ge Wang, Chen-Yue Li, Wen-Jing Liu, Wen-Qiong Wang, Li-Jiang Xuan
• Journal: Natural product research (Nat Prod Res) Vol. 37 Issue 4 Pg. 571-578 (Feb 2023) ISSN: 1478-6427 [Electronic] England
• PMID: 35616360 (Publication Type: Journal Article)

Chemical References

• Glycosides
• Anti-Inflammatory Agents
• Phenols

Topics

• Mice
• Animals
• Molecular Structure
• Ilex (chemistry)
• Plant Bark (chemistry)
• Glycosides (chemistry)
• Anti-Inflammatory Agents (chemistry)
• Phenols (analysis)