Abstract | BACKGROUND: CASE PRESENTATION: In both cases, the pathological diagnosis from transurethral tumor resection showed that they were androgen indifferent prostate cancer ( AIPC), including aggressive variant prostate cancer (AVPC) in Case 1 and treatment-induced neuroendocrine differentiation prostate cancer (NEPC) in Case 2. In Case 1, Loss of genetic heterozygosity (LOH) of BRCA2 and gene amplification of KRAS was identified from the urethra polyps. In Case 2, homozygous deletion was observed in PTEN, and LOH without mutation was observed in RB1. CONCLUSION: These are the first reports of two cases of urinary tract metastasis of AIPC.
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Authors | Tsukasa Masuda, Takeo Kosaka, Kohei Nakamura, Hiroshi Hongo, Kazuyuki Yuge, Hiroshi Nishihara, Mototsugu Oya |
Journal | BMC medical genomics
(BMC Med Genomics)
Vol. 15
Issue 1
Pg. 118
(05 21 2022)
ISSN: 1755-8794 [Electronic] England |
PMID | 35598018
(Publication Type: Case Reports, Journal Article, Review, Research Support, Non-U.S. Gov't)
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Copyright | © 2022. The Author(s). |
Chemical References |
- Androgens
- Receptors, Androgen
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Topics |
- Androgens
- Homozygote
- Humans
- Male
- Prostatic Neoplasms
(genetics, pathology)
- Receptors, Androgen
(genetics)
- Sequence Deletion
- Urinary Tract
(pathology)
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