Crosstalk between lncRNAs in the apoptotic pathway and therapeutic targets in cancer.

Abstract

The assertion that a significant portion of the mammalian genome has not been translated and that non-coding RNA accounts for over half of polyadenylate RNA have received much attention. In recent years, increasing evidence proposes non-coding RNAs (ncRNAs) as new regulators of various cellular processes, including cancer progression and nerve damage. Apoptosis is a type of programmed cell death critical for homeostasis and tissue development. Cancer cells often have inhibited apoptotic pathways. It has recently been demonstrated that up/down-regulation of various lncRNAs in certain types of tumors shapes cancer cells' response to apoptotic stimuli. This review discusses the most recent studies on lncRNAs and apoptosis in healthy and cancer cells. In addition, the role of lncRNAs as novel targets for cancer therapy is reviewed here. Finally, since it has been shown that lncRNA expression is associated with specific types of cancer, the potential for using lncRNAs as biomarkers is also discussed.

• Authors: Nasim Ebrahimi, Sahar Parkhideh, Setare Samizade, Alireza Nasr Esfahani, Sahar Samsami, Elnaz Yazdani, Samaneh Adelian, Siavash Rahimian Chaleshtori, Kamal Shah-Amiri, Amirhossein Ahmadi, Amir Reza Aref
• Journal: Cytokine & growth factor reviews (Cytokine Growth Factor Rev) Vol. 65 Pg. 61-74 (06 2022) ISSN: 1879-0305 [Electronic] England
• PMID: 35597701 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2022 Elsevier Ltd. All rights reserved.

Chemical References

• RNA, Long Noncoding
• RNA, Messenger

Topics

• Animals
• Apoptosis
• Humans
• Neoplasms (drug therapy, therapy)
• RNA, Long Noncoding (genetics, metabolism, therapeutic use)
• RNA, Messenger