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A single-molecular ruthenium(II) complex-based NIR-II fluorophore for enhanced chemo-photothermal therapy.

Abstract
Novel NIR-II Ru(II) polypyridyl fluorophore Ru-1 dots for synergistic chemo-photothermal therapy against 4T1 tumors were designed and synthesized. Guided by in vivo NIR-II fluorescence imaging, the synergistic therapeutic efficacy, intracellular delivery, and biodistribution of the Ru-1 dots were precisely tracked in real-time.
AuthorsQianqian Li, Yishen Liu, Bingshan Zhao, Jiapeng Lei, Siyu Lu, Wanxia Gong, Ke Liang, Junzhu Wu, Xuechuan Hong, Yuling Xiao
JournalChemical communications (Cambridge, England) (Chem Commun (Camb)) Vol. 58 Issue 45 Pg. 6546-6549 (Jun 01 2022) ISSN: 1364-548X [Electronic] England
PMID35579558 (Publication Type: Journal Article)
Chemical References
  • Fluorescent Dyes
  • Ruthenium
Topics
  • Cell Line, Tumor
  • Fluorescent Dyes
  • Nanoparticles
  • Phototherapy (methods)
  • Photothermal Therapy
  • Ruthenium
  • Tissue Distribution

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