Construction of novel antiplatelet modified polyethersulfone membrane and study into its blood compatibility.

Abstract

Blood purification therapy is widely used in patients with renal insufficiency and severe infections, where membrane-associated thrombosis is a side effect. How to improve the hemocompatibility of dialysis membranes and reduce thrombosis is a focus of current research, in which platelets play a key role. However, few dialysis membranes that directly inhibit platelets have been developed to date. In this study, a polyethersulfone (PES) membrane was modified with ticagrelor, a platelet P2Y12 receptor inhibitor, and detailed characterization was performed. The ticagrelor modified PES membrane (TMPES) showed good hydrophilicity and anti-protein adsorption and significantly inhibited platelet adhesion, aggregation, and activation, which demonstrated good antithrombotic properties. In addition, the membrane had excellent red blood cell (RBC) compatibility, anticoagulant, and antiinflammatory effects, which demonstrated superior biosafety in cell and animal experiments. Therefore, the TMPES dialysis membrane could have potential in clinical applications.

• Authors: Xiao Fu, Ting Lei, Shu-Jun Li, Yan-Feng Liu, Jie Peng, Jian-Ping Ning
• Journal: Materials science & engineering. C, Materials for biological applications (Mater Sci Eng C Mater Biol Appl) Vol. 135 Pg. 112659 (Apr 2022) ISSN: 1873-0191 [Electronic] Netherlands
• PMID: 35577688 (Publication Type: Journal Article)
• Copyright: Copyright © 2022 Elsevier B.V. All rights reserved.

Chemical References

• Membranes, Artificial
• Platelet Aggregation Inhibitors
• Polymers
• Sulfones
• polyether sulfone
• Ticagrelor

Topics

• Animals
• Blood Platelets (metabolism)
• Humans
• Membranes, Artificial
• Platelet Aggregation Inhibitors (pharmacology)
• Polymers
• Renal Dialysis
• Sulfones
• Thrombosis (drug therapy)
• Ticagrelor