Development of a Nomogram for Predicting Asymptomatic Coronary Artery Disease in Patients with Ischemic Stroke.

Abstract

BACKGROUND:

Coronary artery stenosis (CAS) ≥50% often coexists in patients with ischemic stroke, which leads to a significant increase in the occurrence of major vascular events after stroke. This study aimed to develop a nomogram for diagnosing the presence of ≥50% asymptomatic CAS in patients with ischemic stroke.

METHODS:

A primary cohort was established that included 275 non-cardioembolic ischemic stroke patients who were admitted from January 2011 to April 2013 to a teaching hospital in southern China. The preoperative data were used to construct two models by the best subset regression and the forward stepwise regression methods, and a nomogram between these models was established. The assessment of the nomogram was carried out by discrimination and calibration in an internal cohort.

RESULTS:

Out of the two models, model 1 contained eight clinical-related variables and exhibited the lowest Akaike Information Criterion value (322.26) and highest concordance index 0.716 (95% CI, 0.654-0.778). The nomogram showed good calibration and significant clinical benefit according to calibration curves and the decision curve analysis.

CONCLUSION:

The nomogram, composed of age, sex, NIHSS score on admission, hypertension history, fast glucose level, HDL cholesterol level, LDL cholesterol level, and presence of ≥50% cervicocephalic artery stenosis, can be used for prediction of ≥50% asymptomatic coronary artery disease (CAD). Further studies are needed to validate the effectiveness of this nomogram in other populations.

• Authors: Jie Yang, Xinguang Yang, Jun Wen, Jiayi Huang, Lihong Jiang, Sha Liao, Chun Lian, Haiyan Yao, Li Huang, Youming Long
• Journal: Current neurovascular research (Curr Neurovasc Res) Vol. 19 Issue 2 Pg. 188-195 ( 2022) ISSN: 1875-5739 [Electronic] United Arab Emirates
• PMID: 35570518 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright© Bentham Science Publishers; For any queries, please email at [email protected].

Topics

• Humans
• Coronary Artery Disease (complications, diagnosis)
• Ischemic Stroke
• Stroke (diagnosis, etiology, epidemiology)
• Nomograms
• China (epidemiology)