Abstract | BACKGROUND: PURPOSE: STUDY DESIGN AND METHODS: Four main biflavonoids in Ginkgo biloba leaves were screened by oleic acid-induced lipid production in HepG2 cells. The non-covalent effects of biflavonoids on the potential targets of atherosclerosis were screened by reverse targeting and molecular dynamics simulation. The interactions between biflavonoids and potential targets were evaluated by an exogenous cell model, which verified the consistency of the simulation results. CONCLUSION:
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Authors | Li-Tao Wang, Han Huang, Yuan-Hang Chang, Yan-Qiu Wang, Jian-Dong Wang, Zi-Hui Cai, Thomas Efferth, Yu-Jie Fu |
Journal | Phytomedicine : international journal of phytotherapy and phytopharmacology
(Phytomedicine)
Vol. 102
Pg. 154053
(Jul 20 2022)
ISSN: 1618-095X [Electronic] Germany |
PMID | 35567993
(Publication Type: Journal Article)
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Copyright | Copyright © 2022. Published by Elsevier GmbH. |
Chemical References |
- Biflavonoids
- Flavonoids
- Oleic Acid
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Topics |
- Atherosclerosis
(drug therapy)
- Biflavonoids
(chemistry, pharmacology)
- Flavonoids
(chemistry)
- Ginkgo biloba
(chemistry)
- Humans
- Oleic Acid
(analysis)
- Plant Leaves
(chemistry)
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