Abstract | BACKGROUND: Serum Dickkopf-1 (Dkk-1) levels are associated with poor ischemic stroke prognosis, although their impact on poststroke depression (PSD) remains unclear. This study aimed to examine the association between serum Dkk-1 levels and PSD. METHODS: Serum Dkk-1 levels were measured in 564 patients with ischemic stroke who participated in the China Antihypertensive Trial in Acute Ischemic Stroke (CATIS). The patients' depression status at 3 months after stroke was assessed using the Hamilton Rating Scale for Depression (HRSD-24). The HRSD score cutoff point for the diagnosis of depression was ≥8. RESULTS: A total of 224 (39.72%) patients were categorized as having PSD 3 months after ischemic stroke. After adjusting for potential confounders, including age, sex, and other important covariates, elevated Dkk-1 levels were associated with an increased risk of PSD (odds ratio [OR], 1.92; 95% confidence interval [CI], 1.14-3.22; Ptrend = 0.037). Similarly, each standard deviation (SD) increase in log-transformed Dkk-1 levels was associated with a 24% increased risk of PSD (OR, 1.24; 95% CI, 1.03-1.49; P = 0.025). Subgroup analyses further confirmed the significant associations between Dkk-1 levels and PSD. CONCLUSION: Higher serum Dkk-1 levels at baseline are independently associated with an increased risk of PSD at 3 months after stroke, suggesting that Dkk-1 levels may be a promising prognostic biomarker for PSD. LIMITATIONS: This study measured serum Dkk-1 levels only in the acute phase of stroke not in different phases; therefore, the relationship between dynamic changes in Dkk-1 levels and PSD could not be evaluated.
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Authors | Kaixin Zhang, Zhengbao Zhu, Mengyao Shi, Daoxia Guo, Yang Liu, Xiaoqing Bu, Bizhong Che, Tian Xu, Pinni Yang, Jing Chen, Tan Xu, Jiang He, Yonghong Zhang |
Journal | Journal of affective disorders
(J Affect Disord)
Vol. 310
Pg. 337-342
(08 01 2022)
ISSN: 1573-2517 [Electronic] Netherlands |
PMID | 35561890
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2022 Elsevier B.V. All rights reserved. |
Topics |
- Brain Ischemia
(complications)
- Depression
(diagnosis)
- Humans
- Ischemic Stroke
- Risk Factors
- Stroke
(complications)
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