Effect of stem cell treatment on burn wounds: A systemic review and a meta-analysis.

Abstract

A meta-analysis was performed to evaluate the effect of stem cells treatment in managing burn wounds. A systematic literature search up to March 2022 incorporated 24 studies reported between 2013 and 2021 including 400 animals with burn wounds at the beginning of the study; 211 were using stem cells treatment, and 189 controlled. Statistical tools like the contentious method were used within a random or fixed-influence model to establish the mean difference (MD) with 95% confidence intervals (CIs) to evaluate the influence of stem cells treatment in managing burn wounds. Stem cells treatment had a significantly higher burn wound healing rate (MD, 15.18; 95% CI, 11.29-19.07, P < .001), higher blood vessel number (MD, 12.28; 95% CI, 10.06-14.51, P < .001), higher vascular endothelial growth factor (MD, 10.24; 95% CI, 7.19-13.29, P < .001), lower interleukin-1 level (MD, -98.48; 95% CI, -155.33 to -41.63, P < .001), and lower tumour necrosis factor α level (MD, -28.71; 95% CI, -46.65 to -10.76, P < .002) compared with control in animals' models with burn wounds. Stem cells treatment had a significantly higher burn wound healing rate, higher blood vessel number, higher vascular endothelial growth factor, lower interleukin-1 level, and lower tumour necrosis factor α level compared with control in animals' models with burn wounds. Further studies are required to validate these findings.

• Authors: Yating Qiao, Qingrong Zhang, Ying Peng, Xianming Qiao, Jun Yan, Bolin Wang, Zhihan Zhu, Zihan Li, Yi Zhang
• Journal: International wound journal (Int Wound J) Vol. 20 Issue 1 Pg. 8-17 (Jan 2023) ISSN: 1742-481X [Electronic] England
• PMID: 35560869 (Publication Type: Meta-Analysis, Journal Article, Systematic Review)
• Copyright: © 2022 The Authors. International Wound Journal published by Medicalhelplines.com Inc (3M) and John Wiley & Sons Ltd.

Chemical References

• Tumor Necrosis Factor-alpha
• Vascular Endothelial Growth Factor A
• Interleukin-1

Topics

• Animals
• Tumor Necrosis Factor-alpha
• Vascular Endothelial Growth Factor A
• Burns (therapy)
• Stem Cells
• Interleukin-1