A Systematic Screening of ADHD-Susceptible Variants From 25 Chinese Parents-Offspring Trios.

Abstract

Attention-deficit/hyperactivity disorder (ADHD) is one of the most prevalent and heritable childhood behavioral disorders. Although a number of ADHD-susceptible regions had been identified, details about the variations of genes and their related patterns involved in ADHD are still lacking. In this study, we collected 25 Chinese parents-offspring trios, each of which consisted of a child diagnosed with ADHD and his/her unaffected parents, and analyzed the variations from whole-genome sequencing data. SNVs in reported ADHD-susceptible regions and on the genes whose functions were related to dopamine were screened, and we identified a set of variants with functional annotations which were specifically detected in ADHD children, including most SNVs in the gene coding region that might impair protein functions and a few SNVs in promoter or 3' untranslated region (3'-UTR) that might affect the regulation of relative gene expression in a transcriptional or posttranscriptional level. All the information may further contribute to the understanding, prediction, prevention, and treatment of ADHD in clinical.

• Authors: Qianqian Li, Yingying Meng, Jingyang Wang, Yuhang Xie, Tian Li, Wei Sun
• Journal: Frontiers in genetics (Front Genet) Vol. 13 Pg. 878036 ( 2022) ISSN: 1664-8021 [Print] Switzerland
• PMID: 35559026 (Publication Type: Journal Article)
• Copyright: Copyright © 2022 Li, Meng, Wang, Xie, Li and Sun.