Precocious puberty related to Leydig cell testicular tumor: the diagnostic imaging keys.

Abstract

BACKGROUND:

We report the challenging case of a 6-year-old boy with precocious puberty related to histologically proven Leydig cell tumor.

CASE PRESENTATION:

Multiparametric ultrasound and magnetic resonance imaging (MRI) was performed. Interesting findings were scarcely or never reported in children and differed from adults Leydig cell tumors s such as the hyperechogenic halo surrounding the lesion and the dominant central vascularization using ultrasensitive Doppler. MRI revealed an enlarged testicle with strong enhancement of a tumor, a tumor apparent diffusion coefficient (ADC) of 600 × 10-3 mm2/s and a lower ADC value of the non-tumor parenchyma compared to the contralateral testis (ADC = 800 × 10-3 mm2/s vs 1100 × 10-3 mm2/s), attributed to the spermatogenesis induced by hormonal impregnation.

CONCLUSION:

We illustrate multiparametric US and MRI findings of a pediatric Leydig cell tumor, including the imaging changes attributed to local hormone secretion, which may be helpful in similar cases.

• Authors: Téodor Grand, Anne-Laure Hermann, Maxime Gérard, Emmanuel Arama, Linda Ouerd, Nada Garrouche, Laurence Rocher
• Journal: European journal of medical research (Eur J Med Res) Vol. 27 Issue 1 Pg. 67 (May 12 2022) ISSN: 2047-783X [Electronic] England
• PMID: 35550623 (Publication Type: Case Reports, Journal Article)
• Copyright: © 2022. The Author(s).

Topics

• Adult
• Child
• Humans
• Leydig Cell Tumor (diagnostic imaging, pathology)
• Leydig Cells (pathology)
• Male
• Puberty, Precocious (diagnostic imaging, etiology, pathology)
• Testicular Neoplasms (diagnostic imaging, pathology)
• Ultrasonography