Expression, functional mechanism and therapy application of long noncoding RNA in β-thalassemia.

Abstract

β-thalassemia (β-thal) is one of the most common genetic diseases in the world, its pathogenesis is extremely complex and there is no effective treatment at present. The birth of children with moderate and severe β-thal brings economic pressure to families, social medical and health services. Long noncoding RNA (lncRNA) is a type of noncoding protein transcripts with a length greater than 200 nucleotides, which is involved in a variety of biological processes, such as cell proliferation, differentiation and chromosome variation and plays an important role in the epigenetic and post-transcriptional regulation of genes. It has potential value in the diagnosis, prevention and treatment of β-thal. LncRNA possesses the characteristics such as tissue specificity, cell specificity, developmental stage specificity, space-time specificity and disease specificity, and its complex interaction network has become a challenge to translate research results into clinical practice. Taking lncRNA as an entry point, in-depth understanding of the function of lncRNA in β-thal and explanation of its related regulatory mechanisms will provide theoretical basis for targeting treatment of β-thal, which can improve the diagnosis and treatment of β-thal.

• Authors: Yali Pan, Liangpu Xu, Hailong Huang
• Journal: Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences (Zhong Nan Da Xue Xue Bao Yi Xue Ban) Vol. 47 Issue 2 Pg. 252-257 (Feb 28 2022) ISSN: 1672-7347 [Print] China
• Vernacular Title: 长链非编码RNA在β地中海贫血中的表达、功能机制及其在治疗中的应用.
• PMID: 35545416 (Publication Type: Journal Article)

Chemical References

• RNA, Long Noncoding

Topics

• Cell Differentiation
• Child
• Gene Expression Regulation
• Humans
• RNA, Long Noncoding (genetics)
• beta-Thalassemia (diagnosis, genetics, therapy)