Abstract |
Six new 14-membered ring cyclopeptide alkaloids, cambodines A-F (1-6), and two known compounds, frangufoline (7) and lotusanine B (8), were isolated from the root bark extract of Ziziphus cambodiana Pierre. Their structures and configurations were established based on 1D and 2D NMR, HRMS, ECD, and X-ray crystallographic data. Compounds 1 and 3 are rare 5(14)-type cyclopeptide alkaloids that possess an imidazolidin-4-one ring in the terminal unit. The cyclopeptides were tested for their in vitro antiplasmodial, antitubercular, and cytotoxic effects against three cancer cell lines. Compound 3 showed significant antiplasmodial activity against the malarial parasite Plasmodium falciparum, with an IC50 value of 6.09 μM.
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Authors | Natthakaln Lomchoey, Panomwan Panseeta, Pornthip Boonsri, Nuttapon Apiratikul, Samran Prabpai, Palangpon Kongsaeree, Sunit Suksamrarn |
Journal | RSC advances
(RSC Adv)
Vol. 8
Issue 33
Pg. 18204-18215
(May 17 2018)
ISSN: 2046-2069 [Electronic] England |
PMID | 35541146
(Publication Type: Journal Article)
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Copyright | This journal is © The Royal Society of Chemistry. |