Abstract | Background:
Hashimoto thyroiditis (HT) is an autoimmune disease which may result in extensive damage of the thyroid gland. Chronic atrophic gastritis (CAG), is the most frequent HT-associated disorder, with anti-parietal cell autoantibodies (APCA) being a screening test for autoimmune CAG. The aim of this study was to investigate, in a cohort of HT patients: a) the prevalence of APCA in an attempt to define their clinical phenotype and b) any possible associations of APCA with other autoimmune diseases and malignancies. Methods: Results: A total of 840 patients with HT were included in the study, from whom 180 (21.4%) had positive APCA. A total of 79 patients (9.4%) had one or more organ-specific autoimmune diseases and 61 (7.3%) had a systemic autoimmune disease. Autoimmune diseases were more frequent in female than in male patients (17.9% versus 10.9%, p = 0.05). APCA-positive patients were older than APCA-negative (54.1 ± 13.5 versus 49.0 ± 14.6, p <0.001) and had more often positive TPOAbs (93.3% versus 83.9%, p=0.001). Gastric neoplasms were documented only in APCA-positive patients (p <0.001). A higher frequency of organ-specific autoimmune diseases was observed in the APCA-positive group (14.4% versus 8%, p = 0.024). In the subgroup of patients with additional autoimmune diseases (n = 140), younger age and positive APCA were independently associated with the presence of organ-specific autoimmunity (OR 0.954, 95% CI 0.927-0.982 and OR 3.100, 95% CI 1.256-7.652, respectively). Papillary thyroid cancer (PTC) occurred in 3.5% of patients (26/29 women). Positive family history for thyroid autoimmunity and negative TPOAbs were the only independent risk factors for PTC among women (OR 3.228, 95% CI 1.173-8.887 and 0.315, 95% 0.113-0.881, respectively). Conclusion: This study reveals for the first time an association of APCA with organ-specific autoimmunity in HT patients. APCA together with patient age were independently associated with the presence of organ-specific autoimmunity. Finally, this study showed an association between APCA and gastric neoplasms in these patients.
|
Authors | Georgios Boutzios, Eleni Koukoulioti, Andreas V Goules, Ioannis Kalliakmanis, Ilias Giovannopoulos, Panayiotis Vlachoyiannopoulos, Haralampos M Moutsopoulos, Athanasios G Tzioufas |
Journal | Frontiers in endocrinology
(Front Endocrinol (Lausanne))
Vol. 13
Pg. 860880
( 2022)
ISSN: 1664-2392 [Print] Switzerland |
PMID | 35528009
(Publication Type: Journal Article)
|
Copyright | Copyright © 2022 Boutzios, Koukoulioti, Goules, Kalliakmanis, Giovannopoulos, Vlachoyiannopoulos, Moutsopoulos and Tzioufas. |
Chemical References |
|
Topics |
- Autoantibodies
- Autoimmune Diseases
(epidemiology)
- Case-Control Studies
- Female
- Graves Disease
- Hashimoto Disease
(epidemiology)
- Humans
- Male
- Stomach Neoplasms
- Thyroid Cancer, Papillary
- Thyroid Neoplasms
(epidemiology)
|