Abstract | BACKGROUND: METHODS: In this study, we used miRNA sequencing and gene expression microarrays from patient tissue to study both the miRNAome and transcriptome traits of AT/RT. RESULTS: Our findings demonstrate that 5 miRNAs were up-regulated, 16 miRNAs were down-regulated, 179 mRNAs were up-regulated and 402 mRNAs were down-regulated in AT/RT. qPCR revealed that hsa-miR-17-5p and MAP7 mRNA were the most significantly differentially expressed miRNA and mRNA in AT/RT tissues. Furthermore, the results from analyses using the miRTarBase database identified MAP7 mRNA as a target gene of hsa-miR-17-5p. CONCLUSIONS: Our findings suggest that the dysregulation of hsa-miR-17-5p may be a pivotal event in AT/RT and miRNAs that may represent potential therapeutic targets and diagnostic biomarkers.
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Authors | Xinke Xu, Hongyao Yuan, Junping Pan, Wei Chen, Cheng Chen, Yang Li, Fangcheng Li |
Journal | BMC cancer
(BMC Cancer)
Vol. 22
Issue 1
Pg. 499
(May 06 2022)
ISSN: 1471-2407 [Electronic] England |
PMID | 35524230
(Publication Type: Journal Article)
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Copyright | © 2022. The Author(s). |
Chemical References |
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Topics |
- Central Nervous System Neoplasms
(genetics)
- Child
- Gene Expression Profiling
- Gene Regulatory Networks
- Humans
- MicroRNAs
(genetics, metabolism)
- RNA, Messenger
(genetics)
- Rhabdoid Tumor
(genetics)
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