Abstract | BACKGROUND: OBJECTIVE: SUBJECTS AND METHODS: A single-center cross-sectional study was conducted on 246 Japanese patients with end-stage renal disease undergoing hemodialysis. Comprehensive medical and dental examinations were performed. The association between severity of periodontitis and T2D was examined by multiple ordered logistic regression analysis. A multiple linear regression model was fitted to assess the association of periodontal probing depth ( PPD) ≥4 mm and the number of missing teeth with T2D (n = 125). A subgroup analysis involving only the patients with T2D was performed to investigate the factors associated with missing teeth among them. RESULTS: After adjusting for confounders, the classification of periodontitis severity was significantly advanced in patients with T2D (odds ratio: 1.64, 95% confidence interval [CI]: 1.02-2.65, p = 0.04). The proportion of PPD≥4 mm sites and the number of missing teeth was significantly associated with T2D (coefficient: 4.1 and 5.7, 95% CI: 0.2-8.0 and 3.4-8.0, p = 0.04 and <0.001, respectively). Subgroup analysis of T2D patients revealed that glycoalbumin levels (coefficient: 0.4, 95% CI: 0.03-0.80, p = 0.03), but not hemoglobin A1c levels (coefficient: 0.8, 95% CI: -1.0-2.7, p = 0.37), were significantly associated with the number of missing teeth. CONCLUSION:
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Authors | Risako Mikami, Koji Mizutani, Yusuke Matsuyama, Tomohito Gohda, Hiromichi Gotoh, Norio Aoyama, Takanori Matsuura, Daisuke Kido, Kohei Takeda, Natsumi Saito, Takeo Fujiwara, Yuichi Izumi, Takanori Iwata |
Journal | PloS one
(PLoS One)
Vol. 17
Issue 5
Pg. e0267494
( 2022)
ISSN: 1932-6203 [Electronic] United States |
PMID | 35522619
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Topics |
- Female
- Humans
- Male
- Cross-Sectional Studies
- Diabetes Mellitus, Type 2
(complications)
- Periodontitis
(complications)
- Renal Dialysis
- Tooth Loss
(complications)
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