Abstract | INTRODUCTION: Micro- ribonucleic acids modulate the immune response by affecting the post-transcriptional expression of genes that influence the proliferation and function of activated immune cells, including regulatory T cells. Individual expressions or patterns in peripheral blood and liver tissue may have diagnostic value, reflect treatment response, or become therapeutic targets. The goals of this review are to present the properties and actions of micro- ribonucleic acids, indicate the key individual expressions in autoimmune hepatitis, and describe prospective clinical applications in diagnosis and management. AREAS COVERED: EXPERT OPINION: Individual micro- ribonucleic acids, miR-21, miR-122, and miR-155, have been associated with biochemical severity, histological grade of inflammation, and pivotal pathogenic mechanisms in autoimmune hepatitis. Antisense oligonucleotides that down-regulate deleterious individual gene expressions, engineered molecules that impair targeting of gene products, and drugs that non-selectively up-regulate the biogenesis of potentially deficient gene regulators are feasible treatment options. Micro- ribonucleic acids constitute an under-evaluated area in autoimmune hepatitis that promises to improve diagnosis, pathogenic concepts, and therapy.
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Authors | Albert J Czaja |
Journal | Expert review of clinical immunology
(Expert Rev Clin Immunol)
Vol. 18
Issue 6
Pg. 591-607
(06 2022)
ISSN: 1744-8409 [Electronic] England |
PMID | 35510750
(Publication Type: Journal Article, Review)
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Chemical References |
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Topics |
- Hepatitis, Autoimmune
(diagnosis, genetics, therapy)
- Humans
- MicroRNAs
(genetics)
- Prospective Studies
- T-Lymphocytes, Regulatory
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