Controlling Immunoregulatory Cell Activity for Effective Photodynamic Therapy of Cancer.

Abstract

Recently, it has become clear that a prerequisite requirement for most cancer therapies is controlling the negative impact of the activity of immunosuppressory cell populations. It is therefore of a considerable interest to develop treatments for containing the operation of major myeloid and lymphoid immunoregulatory cell populations. We have reported that acid ceramidase inhibitor LCL521 effectively overrides the activity of immunoregulatory T cells (Tregs) and myeloid-derived suppressor cells (MDSCs) engaged in the context of tumor response to photodynamic therapy (PDT). The present communication dissects and describes in detail the procedure for the use of LCL521 as an adjuvant to PDT for improved cure rates of treated tumors based on restricting the activity of immunoregulatory cell populations.

• Authors: Mladen Korbelik, Zdzislaw M Szulc, Alicja Bielawska, Duska Separovic
• Journal: Methods in molecular biology (Clifton, N.J.) (Methods Mol Biol) Vol. 2451 Pg. 569-577 ( 2022) ISSN: 1940-6029 [Electronic] United States
• PMID: 35505033 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
• Copyright: © 2022. Springer Science+Business Media, LLC, part of Springer Nature.

Topics

• Humans
• Myeloid-Derived Suppressor Cells (pathology)
• Neoplasms (drug therapy, pathology)
• Photochemotherapy
• T-Lymphocytes (pathology)