Pathological Significance and Prognostic Role of WWC1 in Upper Urinary Tract Urothelial Cancer.

Abstract

BACKGROUND/AIM:

WW and C2 domain-containing 1 (WWC1) protein is a suppressor of malignancies. However, there is no information on the pathological significance of WWC1 in upper urinary tract cancer (UTUC).

PATIENTS AND METHODS:

In this study, WWC1 immunoreactivity was investigated in 152 non-metastatic UTUC samples. The relationships between WWC1 expression and grade, pT stage, proliferative index (using an antibody to Ki-67), and the immunohistochemical expression of matrix metalloproteinase (MMP)-2 and -9 were evaluated.

RESULTS:

WWC1 expression was negatively associated with tumor grade and pT stage (p<0.001). Positive expression of WWC1 was a better predictor of the UTUC recurrence and subsequent metastasis, and the multivariate analysis showed that WWC1 expression was a significant predictor of subsequent metastasis (hazard ratio=0.29, p=0.020). WWC1 expression inversely correlated with the proliferative index (odds ratio=2.59, p=0.023) and expression of MMP9 (odds ratio=2.19, p=0.040) but not with MMP2 expression, by multivariate analyses.

CONCLUSION:

WWC1 expression was negatively associated with malignant aggressiveness via the suppression of cancer cell proliferation and MMP9 expression in patients with UTUC. This suggests WWC1 to be a useful predictor and novel therapeutic target in patients with UTUC.

• Authors: Hiroki Kurata, Kensuke Mitsunari, Tsubasa Kondo, Masahito Masato, Hidenori Ito, Yuta Mukae, Yuichiro Nakamura, Tomohiro Matsuo, Kojiro Ohba, Yasushi Mochizuki, Hideki Sakai, Yasuyoshi Miyata
• Journal: Anticancer research (Anticancer Res) Vol. 42 Issue 5 Pg. 2311-2317 (May 2022) ISSN: 1791-7530 [Electronic] Greece
• PMID: 35489728 (Publication Type: Journal Article)
• Copyright: Copyright © 2022 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

Chemical References

• Intracellular Signaling Peptides and Proteins
• WWC1 protein, human
• Matrix Metalloproteinase 9

Topics

• Carcinoma, Transitional Cell (pathology)
• Female
• Humans
• Intracellular Signaling Peptides and Proteins
• Kidney Neoplasms (pathology)
• Kidney Pelvis (pathology)
• Male
• Matrix Metalloproteinase 9
• Prognosis
• Ureteral Neoplasms (pathology)
• Urologic Neoplasms (pathology)