Abstract | BACKGROUND: RESULTS: We developed a longer-circulating, inflammation-sensing, ROS-scavenging versatile nanoplatform by stably loading catalase-mimicking 1-dodecanethiol stabilized Mn3O4 (dMn3O4) nanoparticles inside ROS-sensitive nanomicelles (PTC), resulting in an ROS-sensitive nanozyme (PTC-M). Hydrophobic dMn3O4 nanoparticles were loaded inside PTC micelles to prevent premature release during circulation and act as a therapeutic agent by ROS-responsive release of loaded dMn3O4 once it reached the inflammation site. CONCLUSIONS: The findings of our study demonstrated the successful attenuation of inflammation and apoptosis in the IRI mice kidneys, suggesting that PTC-M nanozyme could possess promising potential in AKI therapy. This study paves the way for high-performance ROS depletion in treating various inflammation-related diseases.
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Authors | Hong Sang Choi, Ansuja Pulickal Mathew, Saji Uthaman, Arathy Vasukutty, In Jin Kim, Sang Heon Suh, Chang Seong Kim, Seong Kwon Ma, Sontyana Adonijah Graham, Soo Wan Kim, In-Kyu Park, Eun Hui Bae |
Journal | Journal of nanobiotechnology
(J Nanobiotechnology)
Vol. 20
Issue 1
Pg. 205
(Apr 27 2022)
ISSN: 1477-3155 [Electronic] England |
PMID | 35477452
(Publication Type: Journal Article)
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Copyright | © 2022. The Author(s). |
Chemical References |
- Reactive Oxygen Species
- Catalase
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Topics |
- Acute Kidney Injury
(drug therapy)
- Animals
- Catalase
- Female
- Humans
- Hypoxia
- Inflammation
(drug therapy)
- Male
- Mice
- Oxidative Stress
- Reactive Oxygen Species
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