Abstract | BACKGROUND: Previous cross-sectional studies have shown that several circulating microRNA levels are associated with hypertension, but there are no prospective studies among general populations. OBJECTIVE: We evaluated the impact of circulating inflammatory- and oxidative stress-responsive microRNAs on changes in blood pressure and the development of hypertension in normotensive Japanese. METHOD: The study subjects were 84 normotensive participants (33 men and 51 women) who were given a health examination in both 2012 and 2017. In five years, 29 participants developed hypertension. Serum levels of miRNAs (miR-21, miR-27a, and miR-133a) were measured using qRT-PCR. Odds ratios ( ORs) and 95% confidence intervals (CIs) for incident hypertension were estimated by logistic regression analysis. RESULTS: Serum miR-27a and -133a levels were lower in newly hypertensive subjects compared with normotensive subjects. With 1-unit lower serum miR-27a and -133a, the confounders adjusted ORs and 95% CI for incident hypertension were 0.84 (0.72-0.96) and 0.75 (0.58-0.91), respectively. The group with high levels of serum miR-27a and -133a had lower ORs than the group with low levels of these miRNAs (OR and 95% CI of miR-27a: 0.29, 0.08-0.91; miR-133a: 0.08, 0.01-0.37, respectively). CONCLUSIONS:
|
Authors | Koji Suzuki, Hiroya Yamada, Ryosuke Fujii, Eiji Munetsuna, Mirai Yamazaki, Yoshitaka Ando, Koji Ohashi, Hiroaki Ishikawa, Genki Mizuno, Yohiski Tsuboi, Shuji Hashimoto, Nobuyuki Hamajima |
Journal | Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals
(Biomarkers)
Vol. 27
Issue 5
Pg. 496-502
(Jul 2022)
ISSN: 1366-5804 [Electronic] England |
PMID | 35465807
(Publication Type: Journal Article)
|
Chemical References |
- Biomarkers
- Circulating MicroRNA
- MIRN133 microRNA, human
- MIRN27 microRNA, human
- MicroRNAs
|
Topics |
- Biomarkers
- Blood Pressure
- Circulating MicroRNA
(genetics)
- Female
- Humans
- Hypertension
(diagnosis, epidemiology, genetics)
- Male
- MicroRNAs
(genetics)
|